Simple Summary NRF2-activated or NRF2-addicted cancers show high incidence,
especially in esophageal squamous cell carcinoma (ESCC). ESCC with high NRF2 …

Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a
crucial role in maintaining metabolic balance and preventing insulin resistance, both key …

Clinical evidence has revealed that high-level activation of NRF2 caused by somatic
mutations in NRF2 (NFE2L2) is frequently detected in esophageal squamous cell carcinoma …

Esophageal cancer is among the most common tumors in the world and is associated with
poor outcomes, with a 5-year survival rate of about 10–20%. Two main histological subtypes …

While it is well established that the KEAP1-NRF2 pathway regulates the main inducible
cellular response to oxidative stress, this cytoprotective function of NRF2 could become …

Esophageal squamous cell carcinoma (ESCC) is characterized by the development of
cancer in the esophageal squamous epithelium through a step-by-step accumulation of …

Epithelial tissues use homeostatic defence mechanisms to actively expel aberrant or
genetically mutant cells and prevent disease. When present in healthy tissues in low …

In the human esophagus, somatic cancer-associated mutations can occur within distinct
clonal populations, some of which are selected over time. 1 In mice in which Cre-mediated …

The esophageal epithelium is a stratified squamous tissue. Maintenance of the esophageal
epithelial proliferation-differentiation gradient is critical as esophageal epithelium is the first …