The regulation and functions of DNA and RNA G-quadruplexes
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …
structures form through self-recognition of guanines into stacked tetrads, and considerable …
Telomeres—structure, function, and regulation
W Lu, Y Zhang, D Liu, Z Songyang, M Wan - Experimental cell research, 2013 - Elsevier
In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful
replication of genetic materials and protection against DNA damage signals, to ensure …
replication of genetic materials and protection against DNA damage signals, to ensure …
[HTML][HTML] Telomeric G-quadruplexes are a substrate and site of localization for human telomerase
AL Moye, KC Porter, SB Cohen, T Phan… - Nature …, 2015 - nature.com
It has been hypothesized that G-quadruplexes can sequester the 3′ end of the telomere
and prevent it from being extended by telomerase. Here we purify and characterize stable …
and prevent it from being extended by telomerase. Here we purify and characterize stable …
G‐quadruplex nucleic acids and human disease
Y Wu, RM Brosh Jr - The FEBS journal, 2010 - Wiley Online Library
Alternate DNA structures that deviate from B‐form double‐stranded DNA such as G‐
quadruplex (G4) DNA can be formed by sequences that are widely distributed throughout …
quadruplex (G4) DNA can be formed by sequences that are widely distributed throughout …
[HTML][HTML] Regulation of telomere length by G-quadruplex telomere DNA-and TERRA-binding protein TLS/FUS
K Takahama, A Takada, S Tada, M Shimizu… - Chemistry & biology, 2013 - cell.com
Mammalian telomeres comprise noncoding TTAGGG repeats in double-stranded regions
with a single-stranded TTAGGG repeat 3′ overhang and are bound by a multiprotein …
with a single-stranded TTAGGG repeat 3′ overhang and are bound by a multiprotein …
G-quadruplex formation at the 3′ end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase
Telomere G-quadruplex is emerging as a promising anti-cancer target due to its inhibition to
telomerase, an enzyme expressed in more than 85% tumors. Telomerase-mediated …
telomerase, an enzyme expressed in more than 85% tumors. Telomerase-mediated …
[HTML][HTML] Recent developments in small-molecule ligands of medicinal relevance for harnessing the anticancer potential of G-quadruplexes
L Savva, SN Georgiades - Molecules, 2021 - mdpi.com
G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …
recent years as novel targets, with untapped potential for anticancer research. Their …
[PDF][PDF] Magnesium and cancer: a dangerous liason
S Castiglioni, JAM Maier - Magnesium research, 2011 - mgwater.com
A complex relationship links magnesium and cancer. The aim of this review is to revisit
current knowledge concerning the contribution of magnesium to tumorigenesis, from …
current knowledge concerning the contribution of magnesium to tumorigenesis, from …
Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae
JS Smith, Q Chen, LA Yatsunyk, JM Nicoludis… - Nature structural & …, 2011 - nature.com
Telomere capping conceals chromosome ends from exonucleases and checkpoints, but the
full range of capping mechanisms is not well defined. Telomeres have the potential to form G …
full range of capping mechanisms is not well defined. Telomeres have the potential to form G …
[HTML][HTML] CST meets shelterin to keep telomeres in check
MJ Giraud-Panis, MT Teixeira, V Géli, E Gilson - Molecular cell, 2010 - cell.com
Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-
Ten1). Recent data show that CST components are conserved and required for telomere …
Ten1). Recent data show that CST components are conserved and required for telomere …