Viral membrane fusion: a dance between proteins and lipids

JM White, AE Ward, L Odongo… - Annual review of …, 2023 - annualreviews.org
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …

Visualizing intermediate stages of viral membrane fusion by cryo-electron tomography

SM Kephart, N Hom, KK Lee - Trends in Biochemical Sciences, 2024 - cell.com
Protein-mediated membrane fusion is the dynamic process where specialized protein
machinery undergoes dramatic conformational changes that drive two membrane bilayers …

Transient opening of trimeric prefusion RSV F proteins

MSA Gilman, P Furmanova-Hollenstein… - Nature …, 2019 - nature.com
The respiratory syncytial virus (RSV) F glycoprotein is a class I fusion protein that mediates
viral entry and is a major target of neutralizing antibodies. Structures of prefusion forms of …

Structural and cellular biology of rhabdovirus entry

L Belot, A Albertini, Y Gaudin - Advances in virus research, 2019 - Elsevier
Rhabdoviruses are enveloped viruses with a negative-sense single strand RNA genome
and are widespread among a great variety of organisms. In their membrane, they have a …

Structural intermediates in the low pH-induced transition of influenza hemagglutinin

J Gao, M Gui, Y Xiang - PLoS Pathogens, 2020 - journals.plos.org
The hemagglutinin (HA) glycoproteins of influenza viruses play a key role in binding host
cell receptors and in mediating virus-host cell membrane fusion during virus infection. Upon …

The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells

J Koch, Q Xin, M Obr, A Schäfer, N Rolfs… - PLoS …, 2023 - journals.plos.org
Toscana virus is a major cause of arboviral disease in humans in the Mediterranean basin
during summer. However, early virus-host cell interactions and entry mechanisms remain …

Crystal structure of Mokola virus glycoprotein in its post-fusion conformation

L Belot, M Ouldali, S Roche, P Legrand… - PLoS …, 2020 - journals.plos.org
Mokola virus (MOKV) belongs to the lyssavirus genus. As other genus members—including
rabies virus (RABV)—it causes deadly encephalitis in mammals. MOKV entry into host cells …

The stabilities of the soluble ectodomain and fusion peptide hairpins of the Influenza virus hemagglutinin subunit II protein are positively correlated with membrane …

A Ranaweera, PU Ratnayake, DP Weliky - Biochemistry, 2018 - ACS Publications
Cellular entry of influenza virus is mediated by the viral protein hemagglutinin (HA), which
forms an initial complex of three HA1 and three HA2 subunits. Each HA2 includes a fusion …

[HTML][HTML] Early Virus–Host Cell Interactions

PY Lozach - Journal of Molecular Biology, 2018 - ncbi.nlm.nih.gov
Viruses are particles with diverse shapes and sizes, ranging from a few dozen nanometers
to micrometers. They are made up of repetitive blocks of proteins, and sometimes, lipids and …

[PDF][PDF] Inaugural dissertation for obtaining the doctoral degree of the Combined Faculty of Mathematics, Engineering and Natural Sciences

MSJ Koch - bunyavirus.org
The term" zoonosis" is derived from the Greek words" zoon" and" nosos", meaning animal
and illness. According to the World Health Organization (WHO), it includes any disease or …