The retinoblastoma tumor suppressor (RB) and its related family members p107 and p130
regulate cell proliferation through the transcriptional repression of genes involved in cellular …

Pleiotropically acting eukaryotic corepressors such as retinoblastoma and SIN3 have been
found to physically interact with many widely expressed “housekeeping” genes. Evidence …

Gene expression is controlled by the precise activation and repression of transcription.
Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors …

During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or
permanent G0 in which they are refractory to mitogenic signals. Entry into G0 is usually …

Retinoblastoma (pRb) is a multifunctional regulator, which was likely present in the last
common ancestor of all eukaryotes. The Arabidopsis pRb homolog RETINOBLASTOMA …

Insulin signaling plays key roles in development, growth and metabolism through dynamic
control of glucose uptake, global protein translation and transcriptional regulation. Altered …

Retinoblastoma tumor suppressor proteins (Rb) are highly conserved metazoan
transcriptional corepressors involved in regulating the expression of thousands of genes …

The Drosophila testis has been fundamental to understanding how stem cells interact with
their endogenous microenvironment, or niche, to control organ growth in vivo. Here, we …

Abstract Specification of cellular polarity is vital to normal tissue development and function.
Pioneering studies in Drosophila and C. elegans have elucidated the composition and …

Transcriptional regulation in eukaryotic cells involves the activity of multifarious DNA-binding
transcription factors and recruited corepressor complexes. Together, these complexes …