[HTML][HTML] Decoding cell death signals in liver inflammation
Inflammation can be either beneficial or detrimental to the liver, depending on multiple
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …
factors. Mild (ie, limited in intensity and destined to resolve) inflammatory responses have …
Mitochondrial glutathione, a key survival antioxidant
Mitochondria are the primary intracellular site of oxygen consumption and the major source
of reactive oxygen species (ROS), most of them originating from the mitochondrial …
of reactive oxygen species (ROS), most of them originating from the mitochondrial …
Caspase-7 activates ASM to repair gasdermin and perforin pores
Among the caspases that cause regulated cell death, a unique function for caspase-7 has
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …
remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically …
Role of ceramides in nonalcoholic fatty liver disease
M Pagadala, T Kasumov, AJ McCullough… - Trends in endocrinology …, 2012 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is a chronic disease with a histological spectrum
ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH). The latter is …
ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH). The latter is …
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications
Acid sphingomyelinase (ASM) is an important lipid-metabolizing enzyme cleaving
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further …
sphingomyelin to ceramide, mainly within lysosomes. Acid ceramidase (AC) further …
Roles and regulation of secretory and lysosomal acid sphingomyelinase
Acid sphingomyelinase occupies a prominent position in sphingolipid catabolism, catalyzing
the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Enzymatic dysfunction …
the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Enzymatic dysfunction …
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione
F Caballero, A Fernández, N Matías, L Martínez… - Journal of Biological …, 2010 - ASBMB
The pathogenesis and treatment of nonalcoholic steatohepatitis (NASH) are not well
established. Feeding a diet deficient in both methionine and choline (MCD) is one of the …
established. Feeding a diet deficient in both methionine and choline (MCD) is one of the …
Sphingolipids in non-alcoholic fatty liver disease and hepatocellular carcinoma: ceramide turnover
J Simon, A Ouro, L Ala-Ibanibo, N Presa… - International Journal of …, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as one of the main causes of chronic
liver disease worldwide. NAFLD comprises a group of conditions characterized by the …
liver disease worldwide. NAFLD comprises a group of conditions characterized by the …
Tumor necrosis factor-mediated cell death: to break or to burst, that's the question
F Van Herreweghe, N Festjens, W Declercq… - Cellular and Molecular …, 2010 - Springer
In this review, we discuss the signal-transduction pathways of three major cellular responses
induced by tumor necrosis factor (TNF): cell survival through NF-κB activation, apoptosis …
induced by tumor necrosis factor (TNF): cell survival through NF-κB activation, apoptosis …