Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

The induction of type-I interferons (IFN-Is) is important for the efficacy of chemotherapy. By
investigating the role of amino acids in regulation of IFN-I production under chemo-drug …

Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …

Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-
associated degradation (ERAD) plays a critical role in many physiological processes in …

Recent studies using cell type–specific knockout mouse models have improved our
understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA …

Endoplasmic reticulum-associated degradation (ERAD) plays indispensable roles in many
physiological processes; however, the nature of endogenous substrates remains largely …

SEL1L-mediated endoplasmic reticulum-associated degradation (ERAD) plays critical roles
in controlling protein homeostasis by degrading misfolded or terminal unfolded proteins …

The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and
degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is …

Abstract The SEL1L-HRD1 protein complex represents the most conserved branch of
endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in …

Abstract The Stimulator of Interferon Genes (STING) has a crucial role in mediating the
immune response against cytosolic double-stranded DNA (dsDNA) and its activation is …