Although the genetic origins underpinning congenital heart disease (CHD) have been
extensively studied, genes, by themselves, do not entirely predict phenotypes, which result …

Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery but is associated
with acute kidney injury (AKI), which carries considerable morbidity and mortality. In this …

Acute kidney injury (AKI) is a common cause of morbidity after congenital heart disease
surgery. Progress on diagnosis and therapy remains limited, however, in part due to poor …

Background Cardiac surgery-associated acute kidney injury (AKI) can increase the mortality
and morbidity, and the incidence of chronic kidney disease, in critically ill survivors. The …

Background Female infants with congenital heart disease (CHD) face significantly higher
postoperative mortality rates after adjusting for cardiac complexity. Sex differences in …

Purine intermediates play important roles in physiological function and participate in the
kidney disorders, while a targeted quantification of the metabolic alterations in the purine …

Acute kidney injury (AKI) is a common and serious clinical syndrome that involves complex
interplay between different cellular, molecular, metabolic and immunologic mechanisms …

Introduction The incidence of adverse short-term outcomes for infants who undergo complex
congenital heart disease (CHD) surgery with cardiopulmonary bypass (CPB) is still high …

Objective Fetal cardiopulmonary bypass (CPB) is essential to fetal heart surgery, while its
development is limited by vital organ dysfunction after CPB. Studying organ metabolism may …

Acute kidney injury (AKI) is a common cause of morbidity after congenital heart disease
surgery. Progress on diagnosis and therapy remains limited, however, in part due to poor …