[HTML][HTML] Unravelling how single-stranded DNA binding protein coordinates DNA metabolism using single-molecule approaches
Single-stranded DNA-binding proteins (SSBs) play vital roles in DNA metabolism. Proteins
of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double …
of the SSB family exclusively and transiently bind to ssDNA, preventing the DNA double …
[HTML][HTML] Helicase: A genetic tool for providing stress tolerance in plants
Alteration of stress (abiotic and biotic) constitutes one of the major problems for normal
plants health. In the present scenario, new molecular tools are broadly utilized to improve …
plants health. In the present scenario, new molecular tools are broadly utilized to improve …
[HTML][HTML] Hachiman is a genome integrity sensor
Hachiman is a broad-spectrum antiphage defense system of unknown function. We show
here that Hachiman comprises a heterodimeric nuclease-helicase complex, HamAB. HamA …
here that Hachiman comprises a heterodimeric nuclease-helicase complex, HamAB. HamA …
[HTML][HTML] BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapy
K Wojnicki, A Kaczmarczyk, B Wojtas… - Cell Death Discovery, 2023 - nature.com
Most of anti-tumour therapies eliminate neoplastic cells by introducing DNA damage which
ultimately triggers cell death. These effects are counteracted by activated DNA repair …
ultimately triggers cell death. These effects are counteracted by activated DNA repair …
[HTML][HTML] Characterization of human XPD helicase activity with single-molecule magnetic tweezers
C Mao, M Mills - Biophysical Journal, 2024 - cell.com
XPD helicase is a DNA-unwinding enzyme involved in DNA repair. As part of TFIIH, XPD
opens a repair bubble in DNA for access by proteins in the nucleotide excision repair …
opens a repair bubble in DNA for access by proteins in the nucleotide excision repair …
The roles of non-productive complexes of DNA repair proteins with DNA lesions
I Tessmer - DNA repair, 2023 - Elsevier
A multitude of different types of lesions is continuously introduced into the DNA inside our
cells, and their rapid and efficient repair is fundamentally important for the maintenance of …
cells, and their rapid and efficient repair is fundamentally important for the maintenance of …
[HTML][HTML] Characterization of the Escherichia coli XPD/Rad3 iron-sulfur helicase YoaA in complex with the DNA polymerase III clamp loader subunit chi (χ)
SJ Weeks-Pollenz, Y Ali, LA Morris, VA Sutera… - Journal of Biological …, 2023 - ASBMB
Escherichia coli YoaA aids in the resolution of DNA damage that halts DNA synthesis in vivo
in conjunction with χ, an accessory subunit of DNA polymerase III. YoaA and χ form a …
in conjunction with χ, an accessory subunit of DNA polymerase III. YoaA and χ form a …
Single-stranded DNA binding protein hitches a ride with the Escherichia coli YoaA-χ helicase
SJ Weeks-Pollenz, MJ Petrides, R Davis, KK Harris… - bioRxiv, 2024 - biorxiv.org
The Escherichia coli XPD/Rad3-like helicase, YoaA, and DNA polymerase III subunit, χ, are
involved in E. coli DNA damage tolerance and repair. YoaA and χ promote tolerance to the …
involved in E. coli DNA damage tolerance and repair. YoaA and χ promote tolerance to the …
[HTML][HTML] Single-molecule insights into repetitive helicases
YM Zhang, B Li, WQ Wu - Journal of Biological Chemistry - jbc.org
Helicases are ubiquitous motors involved in almost all aspects of nucleic acid metabolism;
therefore, revealing their unwinding behaviors and mechanisms is fundamentally and …
therefore, revealing their unwinding behaviors and mechanisms is fundamentally and …
Characterization of the Escherichia coli XPD/Rad3-Like Helicases
SW Pollenz - 2024 - search.proquest.com
XPD/Rad3-like helicases are critical genome maintenance enzymes found in all forms of life.
The four human XPD/Rad3-like helicases are involved in various DNA repair pathways and …
The four human XPD/Rad3-like helicases are involved in various DNA repair pathways and …