Knowledge of the molecular genetic basis of resistance to antituberculous agents has
advanced rapidly since we reviewed this topic 3 years ago. Virtually all isolates resistant to …

The era of modern, predictably effective tuberculosis chemotherapy began in 1952. Since
then, strains of Mycobacterium tuberculosis have acquired resistance to various drugs, thus …

Summary Background The Xpert MTB/RIF test (Cepheid, Sunnyvale, CA, USA) can detect
tuberculosis and its multidrug-resistant form with very high sensitivity and specificity in …

Control of tuberculosis is threatened by widespread emergence of drug resistance in
Mycobacterium tuberculosis. Understanding the molecular basis of resistance might lead to …

Mycobacterium tuberculosis, which causes tuberculosis, is the greatest single infectious
cause of mortality worldwide, killing roughly two million people annually. Estimates indicate …

Findings from the field of evolutionary biology are yielding dramatic insights for health
scientists, especially those involved in the fight against infectious diseases. This book is the …

The primary theme emerging from molecular genetic work conducted with Mycobacterium
tuberculosis and several other mycobacterial species is that resistance is commonly …

The emergence of multidrug-resistant strains of Mycobacterium tuberculosis has resulted in
increased interest in the fluoroquinolones (FQs) as antituberculosis agents. To investigate …

HIV/AIDS pandemic has caused a resurgence of TB, resulting in increased morbidity and
mortality worldwide. HIV and Mycobacterium tuberculosis have a synergistic interaction; …

Background and Methods The frequency of infection with multidrug-resistant Mycobacterium
tuberculosis is increasing. We reviewed the clinical courses of 171 patients with pulmonary …