Application and perspectives of MALDI–TOF mass spectrometry in clinical microbiology laboratories

E Torres-Sangiao, C Leal Rodriguez, C García-Riestra - Microorganisms, 2021 - mdpi.com
Early diagnosis of severe infections requires of a rapid and reliable diagnosis to initiate
appropriate treatment, while avoiding unnecessary antimicrobial use and reducing …

MALDI mass spectrometry imaging: a potential game-changer in a modern microbiology

M Feucherolles, G Frache - Cells, 2022 - mdpi.com
Nowadays, matrix-assisted laser desorption/ionization time of flight mass spectrometry
(MALDI-TOF MS) is routinely implemented as the reference method for the swift and …

Combination of MALDI-TOF Mass Spectrometry and Machine Learning for Rapid Antimicrobial Resistance Screening: The Case of Campylobacter spp.

M Feucherolles, M Nennig, SL Becker… - Frontiers in …, 2022 - frontiersin.org
While MALDI-TOF mass spectrometry (MS) is widely considered as the reference method for
the rapid and inexpensive identification of microorganisms in routine laboratories, less …

Development of a clinical MALDI-ToF mass spectrometry assay for SARS-CoV-2: Rational design and multi-disciplinary team work

RK Iles, R Zmuidinaite, JK Iles, G Carnell, A Sampson… - Diagnostics, 2020 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus has stretched national
testing capacities to breaking points in almost all countries of the world. The need to rapidly …

Mass spectrometry analytical responses to the SARS-CoV2 coronavirus in review

JH Griffin, KM Downard - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
This article reviews the many and varied mass spectrometry based responses to the SARS-
CoV2 coronavirus amidst a continuing global healthcare crisis. Although RT-PCR is the …

Use of MALDI-TOF mass spectrometry for virus identification: a review

T Do, R Guran, V Adam, O Zitka - Analyst, 2022 - pubs.rsc.org
The coronavirus pandemic caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) directly or indirectly affects every individual worldwide. The fight against …

Perspective on proteomics for virus detection in clinical samples

M Grossegesse, F Hartkopf, A Nitsche… - Journal of Proteome …, 2020 - ACS Publications
One of the most widely used methods to detect an acute viral infection in clinical specimens
is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 …

[HTML][HTML] MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19

P Chivte, Z LaCasse, VDR Seethi, P Bharti… - Journal of Mass …, 2021 - Elsevier
More than a year after the COVID-19 pandemic was declared, the need still exists for
accurate, rapid, inexpensive and non-invasive diagnostic methods that yield high specificity …

Exploratory study on application of MALDI-TOF-MS to detect SARS-CoV-2 infection in human saliva

MM Costa, H Martin, B Estellon, FX Dupé… - Journal of Clinical …, 2022 - mdpi.com
SARS-CoV-2 has caused a large outbreak since its emergence in December 2019. COVID-
19 diagnosis became a priority so as to isolate and treat infected individuals in order to …

Production, titration, neutralisation, storage and lyophilisation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lentiviral pseudotypes

C Di Genova, A Sampson, S Scott, D Cantoni… - Bio …, 2021 - bio-protocol.org
This protocol details a rapid and reliable method for the production and titration of high-titre
viral pseudotype particles with the SARS-CoV-2 spike protein (and D614G or other variants …