Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

The triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial innate immune
receptor associated with a lethal form of early, progressive dementia, Nasu-Hakola disease …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

There is significant need to develop physiologically relevant models for investigating human
astrocytes in health and disease. Here, we present an approach for generating astrocyte …

Microglia are the immune cells of the central nervous system that play important roles in
brain pathologies. Microglia also help shape neuronal circuits during development, via …

Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …