Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …
showed a variety of pharmacological properties, and its derivatives propose a high degree …
Current anti-diabetic agents and their molecular targets: A review
Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …
blood sugar. The frequency of diagnosed cases and consequential increases in medical …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Sulfonamide derivatives as multi-target agents for complex diseases
Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
Synthesis, characterization, and inhibition study of novel substituted phenylureido sulfaguanidine derivatives as α‐glycosidase and cholinesterase inhibitors
A series of six N‐carbamimidoyl‐4‐(3‐substituted phenylureido) benzenesulfonamide
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …
derivatives were synthesized by reaction of sulfaguanidine with aromatic isocyanates. In …
Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors
To discover alternative substances to compounds used to treat many diseases, especially
treating Alzheimer's disease (AD) and Parkinson's disease targeting carbonic anhydrase (h …
treating Alzheimer's disease (AD) and Parkinson's disease targeting carbonic anhydrase (h …
Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes
RA Azzam, RE Elsayed, GH Elgemeie - ACS omega, 2020 - ACS Publications
Sulfonamides and trimethoprim (TMP) drugs are normally used to inhibit the action of
dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes …
dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes …
Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)
GH Elgemeie, RA Azzam, RE Elsayed - Medicinal Chemistry Research, 2019 - Springer
N-sulfonylamino azinones has attracted the interest of numerous researchers and extensive
investigations on their biological activities have been done. The present review provides an …
investigations on their biological activities have been done. The present review provides an …
Synthesis, anticancer and antitubercular properties of new chalcones and their nitrogen-containing five-membered heterocyclic hybrids bearing sulfonamide moiety
LF Castaño, J Quiroga, R Abonia, D Insuasty… - International Journal of …, 2022 - mdpi.com
A new series of sulfonamides, 8a-b, 10, 12, and 14a-b, were synthesized by N-sulfonation
reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16 …
reaction with sulfonyl chlorides 6a-b. Five new series of chalcone-sulfonamide hybrids (16 …
Recent advances in biological active sulfonamide based hybrid compounds Part A: Two-component sulfonamide hybrids
Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …