Limbal epithelial and mesenchymal stem cell therapy for corneal regeneration

S Shukla, SS Shanbhag, F Tavakkoli, S Varma… - Current eye …, 2020 - Taylor & Francis
Corneal pathologies are a major cause of blindness and visual impairment, especially in the
developing world. However, not only is there a global shortage of donor corneal tissue, but a …

Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies

Y Sasamoto, BR Ksander, MH Frank… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: The corneal epithelium is maintained by limbal stem cells (LSCs) that reside in
the basal epithelial layer of the tissue surrounding the cornea termed the limbus. Loss of …

Long-term ocular surface stability in conjunctival limbal autograft donor eyes

AY Cheung, E Sarnicola, EJ Holland - Cornea, 2017 - journals.lww.com
Purpose: To investigate the incidence of limbal stem cell deficiency (LSCD) in donor eyes
after conjunctival limbal autograft (CLAU). Methods: An observational retrospective review …

Conjunctival–limbal autograft

SM Daya - Current opinion in ophthalmology, 2017 - journals.lww.com
Conjunctival–limbal autograft : Current Opinion in Ophthalmology Conjunctival–limbal autograft
: Current Opinion in Ophthalmology Log in or Register Subscribe to journalSubscribe Get new …

Corneal epithelial stem cells for corneal injury

D Bremond-Gignac, H Copin… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Ocular surface diseases with limbal insufficiency represent a therapeutic
challenge for restoring vision. This corneal deficiency includes both classical ocular …

Simple limbal epithelial transplantation: a review on current approach and future directions

D Borroni, B Wowra, V Romano, M Boyadzhieva… - Survey of …, 2018 - Elsevier
Simple limbal epithelial transplantation is a recently developed technique for treating limbal
stem cell deficiency caused by ocular burns. A small limbal biopsy from the donor eye …

Optimized protocol for regeneration of the conjunctival epithelium using the cell suspension technique

M Bertolin, C Breda, S Ferrari, SI Van Acker, N Zakaria… - Cornea, 2019 - journals.lww.com
Purpose: To develop autologous tissue-engineered conjunctival epithelial sheets to be used
as advanced therapy medicinal products for severe ocular surface disorders involving the …

Conjunctival and limbal transplantation from the same living-related bone marrow donor to patients with severe ocular graft-vs-host disease

M Busin, G Giannaccare, L Sapigni… - JAMA …, 2017 - jamanetwork.com
1. Afrogheh AH, Jakobiec FA, Hammon R, et al. Evaluation for high-risk HPV in squamous
cell carcinomas and precursor lesions arising in the conjunctiva and lacrimal sac. Am J Surg …

Biomimetic bioactive biomaterials: the next generation of implantable devices

D Tsiapalis, A De Pieri, M Biggs, A Pandit… - ACS Biomaterials …, 2017 - ACS Publications
Injuries and degenerative conditions continuously increase and financially stress the
already stretched healthcare systems worldwide. Given that advances in medicine have …

MLN4924 Promotes Self-Renewal of Limbal Stem Cells and Ocular Surface Restoration

Q Li, Y Shen, S Wu, H Wei, J Zou, S Xu, Q Ling… - Journal of Personalized …, 2023 - mdpi.com
Objective: To study the role of MLN4924 in corneal stem cell maintenance and corneal injury
repair. Methods: In cell experiments, the Sprague–Dawley (SD) rat corneal epithelial cells …