[HTML][HTML] Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy
MV Preciado, P Valva, A Escobar-Gutierrez… - World journal of …, 2014 - ncbi.nlm.nih.gov
Hepatitis C virus (HCV) infection represents an important public health problem worldwide.
Reduction of HCV morbidity and mortality is a current challenge owned to several viral and …
Reduction of HCV morbidity and mortality is a current challenge owned to several viral and …
Chronic hepatitis C: an overview of evidence on epidemiology and management from a Brazilian perspective
Chronic hepatitis C remains one of the main causes of chronic liver disease worldwide and
presents a variable natural history ranging from minimal changes to advanced fibrosis and …
presents a variable natural history ranging from minimal changes to advanced fibrosis and …
HCV genotypes, characterization of mutations conferring drug resistance to protease inhibitors, and risk factors among blood donors in São Paulo, Brazil
Background Hepatitis C virus (HCV) infection is a global health problem estimated to affect
almost 200 million people worldwide. The aim of this study is to analyze the subtypes and …
almost 200 million people worldwide. The aim of this study is to analyze the subtypes and …
[HTML][HTML] Evaluating drug resistant mutations to HCV NS3 protease inhibitors in iranian Naïve patients
Hepatitis C virus (HCV) is an important causative agent of acute and chronic hepatitis. The
non-structural protein 3 (NS3) of HCV retains two enzymatic domains which are essential for …
non-structural protein 3 (NS3) of HCV retains two enzymatic domains which are essential for …
Baseline hepatitis C virus (HCV) NS3 polymorphisms and their impact on treatment response in clinical studies of the HCV NS3 protease inhibitor faldaprevir
KL Berger, I Triki, M Cartier, M Marquis… - Antimicrobial agents …, 2014 - Am Soc Microbiol
ABSTRACT A challenge to the treatment of chronic hepatitis C with direct-acting antivirals is
the emergence of drug-resistant hepatitis C virus (HCV) variants. HCV with preexisting …
the emergence of drug-resistant hepatitis C virus (HCV) variants. HCV with preexisting …
Pre-existing HCV variants resistant to DAAs and their sensitivity to PegIFN/RBV in Chinese HCV genotype 1b patients
Y Zhang, Y Cao, R Zhang, X Zhang, H Lu, C Wu… - PLoS …, 2016 - journals.plos.org
Background The efficacy of direct-acting antiviral agents (DAAs) could be attenuated by the
presence of resistance-associated variants (RAVs). The aim of this study was to investigate …
presence of resistance-associated variants (RAVs). The aim of this study was to investigate …
Naturally occurring NS3 resistance-associated variants in hepatitis C virus genotype 1: their relevance for developing countries
N Echeverría, G Betancour, F Gámbaro, N Hernández… - Virus Research, 2016 - Elsevier
Hepatitis C virus (HCV) is a major cause of global morbidity and mortality, with an estimated
130–150 million infected individuals worldwide. HCV is a leading cause of chronic liver …
130–150 million infected individuals worldwide. HCV is a leading cause of chronic liver …
Natural prevalence of NS3 gene resistance-associated substitutions (RASs) in patients with chronic hepatitis C from the state of Pará/Brazil
DL da Silva, HM Nunes, PEB Freitas - Virus Research, 2021 - Elsevier
The resistance of hepatitis C virus (HCV) to direct-acting antiviral agents, used in chronic
hepatitis C treatment, consists of a natural process resulting from resistance-associated …
hepatitis C treatment, consists of a natural process resulting from resistance-associated …
Resistance mutations are rare among protease inhibitor treatment-naive hepatitis C genotype-1 patients with or without HIV coinfection
G Lisboa-Neto, CF Noble, JRR Pinho… - Antiviral …, 2015 - journals.sagepub.com
Background HCV has a high replication rate and a lack of proofreading activity, leading to a
greatly diverse viral population. This diversity may lead to emergence of resistant strains in …
greatly diverse viral population. This diversity may lead to emergence of resistant strains in …
NBCZone: Universal three-dimensional construction of eleven amino acids near the catalytic nucleophile and base in the superfamily of (chymo) trypsin-like serine …
AI Denesyuk, MS Johnson, OMH Salo-Ahen… - International journal of …, 2020 - Elsevier
Abstract (Chymo) trypsin-like serine fold proteases belong to the serine/cysteine proteases
found in eukaryotes, prokaryotes, and viruses. Their catalytic activity is carried out using a …
found in eukaryotes, prokaryotes, and viruses. Their catalytic activity is carried out using a …