Deciphering death: a commentary on Gompertz (1825)'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the …
TBL Kirkwood - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
In 1825, the actuary Benjamin Gompertz read a paper,'On the nature of the function
expressive of the law of human mortality, and on a new mode of determining the value of life …
expressive of the law of human mortality, and on a new mode of determining the value of life …
The Williams' legacy: A critical reappraisal of his nine predictions about the evolution of senescence
JM Gaillard, JF Lemaître - Evolution, 2017 - academic.oup.com
Williams' evolutionary theory of senescence based on antagonistic pleiotropy has become a
landmark in evolutionary biology, and more recently in biogerontology and evolutionary …
landmark in evolutionary biology, and more recently in biogerontology and evolutionary …
Repeated intraspecific divergence in life span and aging of African annual fishes along an aridity gradient
R Blažek, M Polačik, P Kačer, A Cellerino… - …, 2017 - academic.oup.com
Life span and aging are substantially modified by natural selection. Across species, higher
extrinsic (environmentally related) mortality (and hence shorter life expectancy) selects for …
extrinsic (environmentally related) mortality (and hence shorter life expectancy) selects for …
The African killifish: A short‐lived vertebrate model to study the biology of sarcopenia and longevity
Sarcopenia, the age‐related decline in muscle function, places a considerable burden on
health‐care systems. While the stereotypic hallmarks of sarcopenia are well characterized …
health‐care systems. While the stereotypic hallmarks of sarcopenia are well characterized …
The relationship between longevity and diet is genotype dependent and sensitive to desiccation in Drosophila melanogaster
AW McCracken, E Buckle… - Journal of Experimental …, 2020 - journals.biologists.com
Dietary restriction (DR) is a key focus in ageing research. Specific conditions and genotypes
were recently found to negate lifespan extension by DR, questioning its universal relevance …
were recently found to negate lifespan extension by DR, questioning its universal relevance …
Do age-specific survival patterns of wild boar fit current evolutionary theories of senescence?
Actuarial senescence is widespread in age-structured populations. In growing populations,
the progressive decline of Hamiltonian forces of selection with age leads to decreasing …
the progressive decline of Hamiltonian forces of selection with age leads to decreasing …
Multiple metazoan life-span interventions exhibit a sex-specific strehler–mildvan inverse relationship between initial mortality rate and age-dependent mortality rate …
The Gompertz equation describes survival in terms of initial mortality rate (parameter a),
indicative of health, and age-dependent acceleration in mortality rate (parameter b) …
indicative of health, and age-dependent acceleration in mortality rate (parameter b) …
[HTML][HTML] On the heterogeneity of human populations as reflected by mortality dynamics
The heterogeneity of populations is used to explain the variability of mortality rates across
the lifespan and their deviations from an exponential growth at young and very old ages. A …
the lifespan and their deviations from an exponential growth at young and very old ages. A …
Age-adjustment expertise in rat models of human diseases
Rat models are the most frequently used models in preclinical and clinical trials because of
having smaller body size, easier maintenance, presenting similar metabolomic and genomic …
having smaller body size, easier maintenance, presenting similar metabolomic and genomic …