Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …

Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Cholesterol is an essential lipid and its synthesis is nutritionally and energetically costly,. In
mammals, cholesterol biosynthesis increases after feeding and is inhibited under fasting …

Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol
biosynthesis, and have been clinically used to treat cardiovascular disease. However, a …

Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in
cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols …

Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular
disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in …

Numerous nascent proteins undergo folding and maturation within the luminal and
membrane compartments of the endoplasmic reticulum (ER). Despite the presence of …