Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and
a heightened pro-inflammatory response: two findings that may be intrinsically linked …

Human microglia play a pivotal role in neurological diseases, but we still have an
incomplete understanding of microglial heterogeneity, which limits the development of …

Microglia, the macrophages of the brain, are vital for brain homeostasis and have been
implicated in a broad range of brain disorders. Neuroinflammation has gained traction as a …

The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …

Lipid metabolism is the major intracellular mechanism driving a variety of cellular functions
such as energy storage, hormone regulation and cell division. Lipids, being a primary …

Alzheimer's disease (AD) is an incurable degenerative disease of the central nervous
system and the most common type of dementia in the elderly. Despite years of extensive …

Besides playing a central role in neuroinflammation, microglia regulate synaptic
development and is involved in plasticity. Converging lines of evidence suggest that these …