[HTML][HTML] Mechanisms, mechanics and function of epithelial–mesenchymal transitions in early development

D Shook, R Keller - Mechanisms of development, 2003 - Elsevier
Epithelial–mesenchymal transitions (EMTs) are an important mechanism for reorganizing
germ layers and tissues during embryonic development. They have both a morphogenic …

Ovarian cancer metastasis: integrating insights from disparate model organisms

H Naora, DJ Montell - Nature reviews cancer, 2005 - nature.com
Despite considerable efforts to improve early detection, and advances in chemotherapy,
metastasis remains a major challenge in the clinical management of ovarian cancer. Studies …

Multicellular rosette formation links planar cell polarity to tissue morphogenesis

JT Blankenship, ST Backovic, JSP Sanny, O Weitz… - Developmental cell, 2006 - cell.com
Elongation of the body axis is accompanied by the assembly of a polarized cytoarchitecture
that provides the basis for directional cell behavior. We find that planar polarity in the …

[HTML][HTML] Patterned gene expression directs bipolar planar polarity in Drosophila

JA Zallen, E Wieschaus - Developmental cell, 2004 - cell.com
During convergent extension in Drosophila, polarized cell movements cause the germband
to narrow along the dorsal-ventral (DV) axis and more than double in length along the …

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

D Bilder - Genes & development, 2004 - genesdev.cshlp.org
Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether
polarity loss might causally contribute to cancer has remained unclear. In Drosophila …

aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells

E Morais-de-Sá, V Mirouse, D St Johnston - Cell, 2010 - cell.com
Summary Bazooka (PAR-3), PAR-6, and aPKC form a complex that plays a key role in the
polarization of many cell types. In epithelial cells, however, Bazooka localizes below PAR-6 …

Polarity proteins in migration and invasion

S Etienne-Manneville - Oncogene, 2008 - nature.com
Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced
tumors, cells invade the surrounding tissue and eventually form metastases. This is …

Mass transit: Epithelial morphogenesis in the Drosophila egg chamber

S Horne‐Badovinac, D Bilder - Developmental dynamics: an …, 2005 - Wiley Online Library
Epithelial cells use a striking array of morphogenetic behaviors to sculpt organs and body
plans during development. Although it is clear that epithelial morphogenesis is largely …

Endocytic control of epithelial polarity and proliferation in Drosophila

H Lu, D Bilder - Nature cell biology, 2005 - nature.com
Intracellular protein transport is a key factor in epithelial cell polarity. Here we report that
mutations in two core components of the vesicle trafficking machinery—a syntaxin and a …

Using Drosophila melanogaster to map human cancer pathways

AM Brumby, HE Richardson - Nature Reviews Cancer, 2005 - nature.com
The development of human cancer is a multistep process, involving the cooperation of
mutations in signalling, cell-cycle and cell-death pathways, as well as interactions between …