[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

The concept of big four: road map from snakebite epidemiology to antivenom efficacy

G Gopal, S Muralidar, D Prakash… - International journal of …, 2023 - Elsevier
Snake envenomation is a life-threatening disease caused by the injection of venom toxins
from the venomous snake bite. Snakebite is often defined as the occupational or domestic …

Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

RR Senji Laxme, S Khochare, S Attarde… - PLoS neglected …, 2021 - journals.plos.org
Background Snakebite in India results in over 58,000 fatalities and a vast number of
morbidities annually. The majority of these clinically severe envenomings are attributed to …

Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy

RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …

[HTML][HTML] Interpopulational variation and ontogenetic shift in the venom composition of Lataste's viper (Vipera latastei, Boscá 1878) from northern Portugal

I Avella, JJ Calvete, L Sanz, W Wüster, F Licata… - Journal of …, 2022 - Elsevier
Lataste's viper (Vipera latastei) is a venomous European viper endemic to the Iberian
Peninsula, recognised as medically important by the World Health Organization. To date, no …

Pharmacological re-assessment of traditional medicinal plants-derived inhibitors as antidotes against snakebite envenoming: A critical review

U Puzari, PA Fernandes, AK Mukherjee - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Traditional healers have used medicinal plants to treat
snakebite envenomation worldwide; however, mostly without scientific validation. There …

Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: implications in antivenom therapy

B Kalita, YN Utkin, AK Mukherjee - Toxins, 2022 - mdpi.com
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …

Advances in the therapeutic application of small-molecule inhibitors and repurposed drugs against snakebite: Miniperspective

U Puzari, PA Fernandes… - Journal of Medicinal …, 2021 - ACS Publications
The World Health Organization has declared snakebite as a neglected tropical disease.
Antivenom administration is the sole therapy against venomous snakebite; however, several …

Quantitative proteomic analysis of venom from Southern India common krait (Bungarus caeruleus) and identification of poorly immunogenic toxins by immune …

A Patra, A Chanda, AK Mukherjee - Expert review of proteomics, 2019 - Taylor & Francis
Objectives: To study the venom proteome composition of Southern India (SI) Common Krait
(Bungarus caeruleus) and immunological cross-reactivity between venom against …

The in vitro laboratory tests and mass spectrometry-assisted quality assessment of commercial polyvalent antivenom raised against the 'Big Four'venomous snakes of …

A Patra, D Banerjee, S Dasgupta, AK Mukherjee - Toxicon, 2021 - Elsevier
India has recorded the maximum snakebite deaths in the world. Intravenous administration
of polyvalent antivenom (PAV) raised against the 'Big Four'venomous snakes of India (Naja …