Reactive oxygen species (ROS) have been described to induce a broad range of redox-
dependent signaling reactions in physiological conditions. Nevertheless, an excessive …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex
1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses …

Abstract 'Turn-on'fluorescence probes for detecting H2O2 in cells are established, but
equivalent tools to monitor the products of its reaction with protein cysteines have not been …

Reactive oxygen species (ROS) can modulate protein function through cysteine oxidation.
Identifying protein targets of ROS can provide insight into uncharacterized ROS-regulated …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Because of the central role ribosomes play for protein translation and ribosome-mediated
mRNA and protein quality control (RQC), the ribosome pool is surveyed and dysfunctional …

Mitochondria are key players in energy production, critical activity for the smooth functioning
of energy-demanding organs such as the muscles, brain, and heart. Therefore …

Cysteine has been exploited as the binding site of covalent drugs. Its high sensitivity to
oxidation is also important for regulating cellular processes. To identify new ligandable …

Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence,
cysteine often has important functions in a protein, be it as the active site or, in extracellular …