Highlights•The antibiotic resistance crisis is jeopardizing feasibility of medical practices.•The
antibiotic resistance crisis is more serious with Gram-negative pathogens.•XDR phenotypes …

The management of infections due to Klebsiella pneumoniae has been complicated by the
emergence of antimicrobial resistance, especially to carbapenems. Resistance to …

This article provides a comprehensive review of currently available treatment options for
infections due to carbapenem-resistant Enterobacteriaceae (CRE). Antimicrobial resistance …

Introduction: In the era of multidrug-resistant, extensively drug-resistant (XDR) and even
pandrug-resistant Gram-negative microorganisms, the medical community is facing the …

Carbapenemase-producing Enterobacteriaceae (CPE) have spread worldwide, causing
serious infections with increasing frequency. CPE are resistant to almost all available …

Escherichia coli is the most common Gram-negative bacterial pathogen, presenting both a
clinical and an epidemiological challenge. In the last decade, several successful multidrug …

The recent surge in multidrug-resistant pathogens combined with the diminishing antibiotic
pipeline has created a growing need to optimize the use of our existing antibiotic …

Critically ill patients with severe infections are at high risk of suboptimal antimicrobial dosing.
The pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobials in these patients …

ABSTRACT Introduction: Multidrug-resistant (MDR) and extensively-drug-resistant (XDR)
Gram-negative bacteria have emerged as a major threat to human health globally. This has …

Objectives The objectives of this study were to assess risk factors for acute kidney injury
(AKI) in patients treated with polymyxin B, a last resort antibiotic against Gram-negative …