Peptide drugs offer distinct advantages in therapeutics; however, their limited stability and
membrane penetration abilities hinder their widespread application. One strategy to …

Based on the structure of a de novo designed miniprotein (LCB1) in complex with the
receptor binding domain (RBD) of the SARS-CoV-2 spike protein, we have generated and …

The outbreak of COVID-19 has resulted in millions of deaths. Despite all attempts that have
been made to combat the pandemic, the re-emergence of new variants complicated SARS …

The emergence of the recent pandemic causing severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has created an alarming situation worldwide. It also prompted …

Stabilization of a peptide conformation via stapling strategy may be realized by the
reversible or more often irreversible connection of side chains being in mutually appropriate …

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus,
is the causative agent responsible for the spread of the COVID19 pandemic across the …

Brought about by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
coronavirus disease (COVID-19) pandemic has resulted in large numbers of worldwide …

HIV-1 integrase (IN), a major protein in the HIV life cycle responsible for integrating viral
cDNA into the host DNA, represents a promising drug target. Small peptides have emerged …

Stapled peptides are a promising class of molecules with potential as highly specific probes
of protein–protein interactions and as therapeutics. Hydrocarbon stapling affects the peptide …

The COVID‐19 pandemic drove a uniquely fervent pursuit to explore the potential of peptide,
antibody, protein, and small‐molecule‐based antiviral agents against severe acute …