It is becoming increasingly clear that the genetic background of mice and rats, even in
inbred strains, can have a profound influence on measures of seizure susceptibility and …

The functionality and stability of the central nervous system (CNS) pabulum, called neural
extracellular matrix (nECM), is paramount for the maintenance of a healthy network. The …

Heterozygous and rare homozygous mutations in PRoline-Rich Transmembrane protein 2
(PRRT2) underlie a group of paroxysmal disorders including epilepsy, kinesigenic …

The intrahippocampal kainate mouse model of mesial temporal lobe epilepsy is increasingly
being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous …

Objective Intracranial (intrahippocampal or intra‐amygdala) administration of kainate in
rodents leads to spatially restricted brain injury and development of focal epilepsy with …

Current understanding of the neurobiology of depression has grown over the past few years
beyond the traditional monoamine theory of depression to include chronic stress …

Binding of the extracellular matrix proteinase urokinase-type plasminogen activator (uPA) to
its receptor, uPAR, regulates tissue remodeling during development and after injury in …

This study was to examine the inhibitory effect of matrine on the proliferation and metastasis
of gastric cancer cells, and to explore the possible mechanisms involved in these processes …

Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures
resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain …

Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator
(uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the …