Bacterial chromosome organization and segregation
A Badrinarayanan, TBK Le… - Annual review of cell and …, 2015 - annualreviews.org
If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …
approximately 1,000 times the length of a cell. Not only must cells massively compact their …
RecA: regulation and mechanism of a molecular search engine
JC Bell, SC Kowalczykowski - Trends in biochemical sciences, 2016 - cell.com
Homologous recombination maintains genomic integrity by repairing broken chromosomes.
The broken chromosome is partially resected to produce single-stranded DNA (ssDNA) that …
The broken chromosome is partially resected to produce single-stranded DNA (ssDNA) that …
Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation
AM Ladouceur, BS Parmar… - Proceedings of the …, 2020 - National Acad Sciences
Once described as mere “bags of enzymes,” bacterial cells are in fact highly organized, with
many macromolecules exhibiting nonuniform localization patterns. Yet the physical and …
many macromolecules exhibiting nonuniform localization patterns. Yet the physical and …
[HTML][HTML] Condensin-and replication-mediated bacterial chromosome folding and origin condensation revealed by Hi-C and super-resolution imaging
Chromosomes of a broad range of species, from bacteria to mammals, are structured by
large topological domains whose precise functional roles and regulatory mechanisms …
large topological domains whose precise functional roles and regulatory mechanisms …
Live-cell superresolution microscopy reveals the organization of RNA polymerase in the bacterial nucleoid
M Stracy, C Lesterlin… - Proceedings of the …, 2015 - National Acad Sciences
Despite the fundamental importance of transcription, a comprehensive analysis of RNA
polymerase (RNAP) behavior and its role in the nucleoid organization in vivo is lacking …
polymerase (RNAP) behavior and its role in the nucleoid organization in vivo is lacking …
[HTML][HTML] Architecture of the Escherichia coli nucleoid
SC Verma, Z Qian, SL Adhya - PLoS genetics, 2019 - journals.plos.org
How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …
influences cellular functions are significant questions in biology. A bacterial genomic DNA …
[HTML][HTML] Four-dimensional imaging of E. coli nucleoid organization and dynamics in living cells
JK Fisher, A Bourniquel, G Witz, B Weiner, M Prentiss… - Cell, 2013 - cell.com
Visualization of living E. coli nucleoids, defined by HupA-mCherry, reveals a discrete,
dynamic helical ellipsoid. Three basic features emerge.(1) Nucleoid density coalesces into …
dynamic helical ellipsoid. Three basic features emerge.(1) Nucleoid density coalesces into …
Organization and segregation of bacterial chromosomes
X Wang, PM Llopis, DZ Rudner - Nature Reviews Genetics, 2013 - nature.com
The bacterial chromosome must be compacted more than 1,000-fold to fit into the
compartment in which it resides. How it is condensed, organized and ultimately segregated …
compartment in which it resides. How it is condensed, organized and ultimately segregated …
[HTML][HTML] Subcellular organization: a critical feature of bacterial cell replication
IV Surovtsev, C Jacobs-Wagner - Cell, 2018 - cell.com
Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …
cellular life, display defined shapes and complex internal organization, showcasing a highly …
[HTML][HTML] Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation
The widely conserved ParABS system plays a major role in bacterial chromosome
segregation. How the components of this system work together to generate translocation …
segregation. How the components of this system work together to generate translocation …