Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …

The type 2 cannabinoid receptor (CB2R) was initially regarded as a peripheral cannabinoid
receptor. However, recent technological advances in gene detection, alongside the …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of
molecules, some with psychoactive effects. At least 4% of the world's adult population uses …

Drug addiction is a chronic relapsing disorder that produces a dramatic global health burden
worldwide. Not effective treatment of drug addiction is currently available probably due to the …

We have recently reported the expression of functional cannabinoid CB2 receptors (CB2Rs)
in midbrain dopamine (DA) neurons in mice. However, little is known whether CB2Rs are …

Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs),
namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions of agonists of CB1 …