Looking at the variety of the thousands of different polypeptides that have been focused on
in the research on the endoplasmic reticulum from the last five decades taught us one …

Many tail-anchored (TA) membrane proteins are targeted to and inserted into the
endoplasmic reticulum (ER) by theguided entry of tail-anchored proteins'(GET) pathway …

Membrane protein biogenesis poses acute challenges to protein homeostasis, and how they
are selectively escorted to the target membrane is not well understood. Here we address this …

Tail-anchored (TA) membrane proteins, accounting for roughly 2% of proteomes, are
primarily targeted posttranslationally to the endoplasmic reticulum membrane by the guided …

Nucleoside-triphosphate hydrolases (NTPases) are a diverse, but essential group of
enzymes found in all living organisms. NTPases that have a GXXXXGK-[S/T] consensus …

The Hsp70 family of molecular chaperones acts as a central 'hub'in the cell that interacts
with numerous newly synthesized proteins to assist in their biogenesis. Apart from its central …

Close coordination between chaperones is essential for protein biosynthesis, including the
delivery of tail-anchored (TA) proteins containing a single C-terminal transmembrane …

Newly synthesized integral membrane proteins must traverse the aqueous cytosolic
environment before arrival at their membrane destination and are prone to aggregation …

Molecular chaperones play key roles in maintaining cellular proteostasis. In addition to
preventing client aggregation, chaperones often relay substrates within a network while …

The conserved signal recognition particle (SRP) cotranslationally delivers~ 30% of the
proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which …