Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …

Reprogramming of somatic cells to a pluripotent embryonic stem cell-like state has been
achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most …

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue
dysfunction and disease. At the cellular level, ageing is associated with reduced function …

Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

Mammalian oocytes can reprogram somatic cells into a totipotent state enabling animal
cloning through somatic cell nuclear transfer (SCNT). However, the majority of SCNT …

Methylation at the 5′ position of cytosine in DNA has important roles in genome function
and is dynamically reprogrammed during early embryonic and germ cell development. The …

Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human
embryonic stem cells (HESCs). Using two genetic lineage-tracing systems, we demonstrate …

Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …

Methylation of position-specific lysine residues in histone N termini is a central modification
for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist …

Global demethylation is part of a conserved program of epigenetic reprogramming to naive
pluripotency. The transition from primed hypermethylated embryonic stem cells (ESCs) to …