As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

The forebrain cholinergic system promotes higher brain function in part by signaling through
the M1 muscarinic acetylcholine receptor (mAChR). During Alzheimer's disease (AD), these …

M1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment
of disorders involving impaired cognitive function. However, a major limitation to testing this …

Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel
treatments for multiple central nervous system (CNS) disorders, including anxiety and …

Degeneration of the cholinergic system is considered to be the underlying pathology that
results in the cognitive deficit in Alzheimer's disease. This pathology is thought to be linked …

Background Brain-derived neurotrophic factor (BDNF) plays a key role in the
pathophysiology and treatment of depression. Recent clinical studies demonstrate that …

Seizures are the manifestation of highly synchronized burst firing of a large population of
cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a …

Background In the neurogenic niches of the adult hippocampus, new functional neurons are
continuously generated throughout life, and generation of these neurons has been …