[HTML][HTML] The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
L Zheng, Z Zhang, P Sheng, A Mobasheri - Ageing research reviews, 2021 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …
How to build a bone: PHOSPHO1, biomineralization, and beyond
S Dillon, KA Staines, JL Millán… - Journal of Bone and …, 2019 - academic.oup.com
Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the
subject of an increasing focus of research. This work has elucidated PHOSPHO1's central …
subject of an increasing focus of research. This work has elucidated PHOSPHO1's central …
Phospholipase A2 inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression
Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in
drug discovery and development, no disease-modifying drug for knee OA has emerged with …
drug discovery and development, no disease-modifying drug for knee OA has emerged with …
[HTML][HTML] Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients
W Zhang, G Sun, S Likhodii, M Liu, E Aref-Eshghi… - Osteoarthritis and …, 2016 - Elsevier
Objective To identify novel biomarker (s) for knee osteoarthritis (OA) using a metabolomics
approach. Method We utilized a two-stage case–control study design. Plasma samples were …
approach. Method We utilized a two-stage case–control study design. Plasma samples were …
Endotypes of primary osteoarthritis identified by plasma metabolomics analysis
S Werdyani, M Liu, H Zhang, G Sun, A Furey… - …, 2021 - academic.oup.com
Objective To identify endotypes of osteoarthritis (OA) by a metabolomics analysis. Methods
Study participants included hip/knee OA patients and controls. Fasting plasma samples …
Study participants included hip/knee OA patients and controls. Fasting plasma samples …
Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis
Objective. To identify novel biomarker (s) for predicting advanced knee OA. Methods. Study
participants were derived from the Newfoundland Osteoarthritis Study and the Tasmania …
participants were derived from the Newfoundland Osteoarthritis Study and the Tasmania …
Time-of-flight secondary ion mass spectrometry-based molecular distribution distinguishing healthy and osteoarthritic human cartilage
Osteoarthritis (OA) is a pathology that ultimately causes joint destruction. The cartilage is
one of the principal affected tissues. Alterations in the lipid mediators and an imbalance in …
one of the principal affected tissues. Alterations in the lipid mediators and an imbalance in …
Inflammatory Effects of Bothrops Phospholipases A2: Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation
V Moreira, E Leiguez, PM Janovits, R Maia-Marques… - Toxins, 2021 - mdpi.com
Phospholipases A2s (PLA2s) constitute one of the major protein groups present in the
venoms of viperid and crotalid snakes. Snake venom PLA2s (svPLA2s) exhibit a remarkable …
venoms of viperid and crotalid snakes. Snake venom PLA2s (svPLA2s) exhibit a remarkable …
Activation of the phosphatidylcholine to lysophosphatidylcholine pathway is associated with osteoarthritis knee cartilage volume loss over time
To identify serum biomarker (s) for predicting knee cartilage volume loss over time, we
studied 139 knee osteoarthritis (OA) patients from a previous 24-month clinical trial cohort …
studied 139 knee osteoarthritis (OA) patients from a previous 24-month clinical trial cohort …
Phospholipases of mineralization competent cells and matrix vesicles: roles in physiological and pathological mineralizations
The present review aims to systematically and critically analyze the current knowledge on
phospholipases and their role in physiological and pathological mineralization undertaken …
phospholipases and their role in physiological and pathological mineralization undertaken …