Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

An immunosuppressive tumour microenvironment is a major obstacle in the control of
pancreatic and other solid cancers,–. Agonists of the stimulator of interferon g enes (STING) …

Background BCMA-specific chimeric antigen receptor-T cells (CAR-Ts) have exhibited
remarkable efficacy in refractory or relapsed multiple myeloma (RRMM); however, primary …

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

The differentiation of IL-10-producing regulatory B cells (Bregs) in response to gut-
microbiota-derived signals supports the maintenance of tolerance. However, whether …

The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Rheumatoid arthritis (RA) is a common, chronic, systemic autoimmune disease, and its
clinical features are the proliferation of joint synovial tissue, the formation of pannus and the …

Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …