Current and emerging therapies for coeliac disease
L Kivelä, A Caminero, DA Leffler… - Nature reviews …, 2021 - nature.com
Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …
The cytokine network in colorectal cancer: Implications for new treatment strategies
H Braumüller, B Mauerer, J Andris, C Berlin, T Wieder… - Cells, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …
limited therapeutic options. CRC is not only a genetic disease with several mutations in …
Coeliac disease pathogenesis: the uncertainties of a well-known immune mediated disorder
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed
individuals and caused by ingestion of gluten in the diet. Great advances have been made …
individuals and caused by ingestion of gluten in the diet. Great advances have been made …
[HTML][HTML] Celiac disease: New therapies on the horizon
T Dieckman, F Koning, G Bouma - Current opinion in pharmacology, 2022 - Elsevier
Abstract Celiac Disease (CeD) is a chronic intestinal disease which occurs in 0.7–1.4% of
the global population. Since the discovery of gluten as its disease-inducing antigen, CeD …
the global population. Since the discovery of gluten as its disease-inducing antigen, CeD …
IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
OJ James, M Vandereyken, JM Marchingo… - Nature …, 2021 - nature.com
Intestinal intraepithelial lymphocytes (IEL) are an abundant population of tissue-resident T
cells that protect and maintain the intestinal barrier. IEL respond to epithelial cell-derived IL …
cells that protect and maintain the intestinal barrier. IEL respond to epithelial cell-derived IL …
[HTML][HTML] New developments in celiac disease treatments
F Buriánek, C Gege, P Marinković - Drug Discovery Today, 2024 - Elsevier
Celiac disease (CeD), an autoimmune disorder triggered by gluten, affects around 1% of the
global population. Standard treatment is a strict gluten-free diet (GFD), which poses …
global population. Standard treatment is a strict gluten-free diet (GFD), which poses …
How future pharmacologic therapies for celiac disease will complement the gluten-free diet
V Discepolo, CP Kelly, F Koning, D Schuppan - Gastroenterology, 2024 - Elsevier
The only proven treatment for celiac disease is adherence to a strict, lifelong, gluten free
diet. However, complete dietary gluten avoidance is challenging and a substantial number …
diet. However, complete dietary gluten avoidance is challenging and a substantial number …
In a large juvenile idiopathic arthritis (JIA) cohort, concomitant celiac disease is associated with family history of autoimmunity and a more severe JIA course: a …
R Naddei, S Di Gennaro, A Guarino, R Troncone… - Pediatric …, 2022 - Springer
Background A higher prevalence of celiac disease (CD) has been reported in patients with
juvenile idiopathic arthritis (JIA) compared to the general population. Factors related to the …
juvenile idiopathic arthritis (JIA) compared to the general population. Factors related to the …
Counteracting interleukin-15 to elucidate its modes of action in physiology and pathology
E Mortier, M Maillasson, A Quéméner - Journal of Interferon & …, 2023 - liebertpub.com
Interleukin (IL)-15 belongs to the common gamma-dependent cytokine family, along with IL-
2, IL-4, IL-7, IL-9, and IL-21. IL-15 is crucial for the homeostasis of Natural Killer (NK) and …
2, IL-4, IL-7, IL-9, and IL-21. IL-15 is crucial for the homeostasis of Natural Killer (NK) and …
The implications of IL-15 trans-presentation on the immune response
TA Waldmann, R Waldmann, JX Lin… - Advances in …, 2022 - Elsevier
Interleukin-15 is a pleiotropic cytokine type I four alpha-helical bundle cytokine that along
with IL-2, IL-4, IL-7, IL-9, and IL-21 shares the common cytokine receptor γ chain, γ c. IL-15 is …
with IL-2, IL-4, IL-7, IL-9, and IL-21 shares the common cytokine receptor γ chain, γ c. IL-15 is …