The great immune escape: understanding the divergent immune response in breast cancer subtypes
Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …
Single-cell RNA sequencing in cancer: Applications, advances, and emerging challenges
G Sun, Z Li, D Rong, H Zhang, X Shi, W Yang… - Molecular Therapy …, 2021 - cell.com
Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …
urgently needed to further clarify the mechanisms of cancer so that better detection and …
Impaired histone inheritance promotes tumor progression
C Tian, J Zhou, X Li, Y Gao, Q Wen, X Kang… - Nature …, 2023 - nature.com
Faithful inheritance of parental histones is essential to maintain epigenetic information and
cellular identity during cell division. Parental histones are evenly deposited onto the …
cellular identity during cell division. Parental histones are evenly deposited onto the …
Intratumor CMS heterogeneity impacts patient prognosis in localized colon cancer
Purpose: The consensus molecular subtypes (CMS) represent a significant advance in the
understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is …
understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is …
Subclonal heterogeneity and evolution in breast cancer
I Mavrommati, F Johnson, GV Echeverria… - NPJ Breast Cancer, 2021 - nature.com
Subclonal heterogeneity and evolution are characteristics of breast cancer that play a
fundamental role in tumour development, progression and resistance to current therapies. In …
fundamental role in tumour development, progression and resistance to current therapies. In …
Mapping spatiotemporal heterogeneity in tumor profiles by integrating high-throughput imaging and omics analysis
PA Patkulkar, AR Subbalakshmi, MK Jolly… - ACS …, 2023 - ACS Publications
Intratumoral heterogeneity associates with more aggressive disease progression and worse
patient outcomes. Understanding the reasons enabling the emergence of such …
patient outcomes. Understanding the reasons enabling the emergence of such …
[HTML][HTML] Towards dual function of autophagy in breast cancer: A potent regulator of tumor progression and therapy response
M Hashemi, MDA Paskeh, S Orouei, P Abbasi… - Biomedicine & …, 2023 - Elsevier
As a devastating disease, breast cancer has been responsible for decrease in life
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …
Atlas of lobular breast cancer models: challenges and strategic directions
Simple Summary Invasive lobular breast cancer (ILC) is the second most common
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …
Implications of tumour heterogeneity on cancer evolution and therapy resistance: lessons from breast cancer
S Thakur, S Haider, R Natrajan - The Journal of Pathology, 2023 - Wiley Online Library
Tumour heterogeneity is pervasive amongst many cancers and leads to disease
progression, and therapy resistance. In this review, using breast cancer as an exemplar, we …
progression, and therapy resistance. In this review, using breast cancer as an exemplar, we …
Genomic properties and clinical outcomes associated with tertiary lymphoid structures in patients with breast cancer
L Wang, S Gong, L Pang, S Zhang, X Zhang, W He - Scientific Reports, 2023 - nature.com
Tertiary lymphoid structures (TLSs) play a crucial role in determining prognosis and
response to immunotherapy in several solid malignancies. Nevertheless, the effect of TLS …
response to immunotherapy in several solid malignancies. Nevertheless, the effect of TLS …