Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

Faithful inheritance of parental histones is essential to maintain epigenetic information and
cellular identity during cell division. Parental histones are evenly deposited onto the …

Purpose: The consensus molecular subtypes (CMS) represent a significant advance in the
understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is …

Subclonal heterogeneity and evolution are characteristics of breast cancer that play a
fundamental role in tumour development, progression and resistance to current therapies. In …

Intratumoral heterogeneity associates with more aggressive disease progression and worse
patient outcomes. Understanding the reasons enabling the emergence of such …

As a devastating disease, breast cancer has been responsible for decrease in life
expectancy of females and its morbidity and mortality are high. Breast cancer is the most …

Simple Summary Invasive lobular breast cancer (ILC) is the second most common
histological subtype of invasive breast cancer, which is noted to have a unique microscopic …

Tumour heterogeneity is pervasive amongst many cancers and leads to disease
progression, and therapy resistance. In this review, using breast cancer as an exemplar, we …

Tertiary lymphoid structures (TLSs) play a crucial role in determining prognosis and
response to immunotherapy in several solid malignancies. Nevertheless, the effect of TLS …