Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …

Genes are transcribed in a discontinuous pattern referred to as RNA bursting, but the
mechanisms regulating this process are unclear. Although many physiological signals …

The glucocorticoid receptor (GR) is a bona fide ligand‐regulated transcription factor. Cloned
in the 80s, the GR has become one of the best‐studied and clinically most relevant members …

Proteins and RNAs inside the cell nucleus are organized into distinct phases, also known as
liquid-liquid phase separated (LLPS) droplet organelles or nuclear bodies. These regions …

Single-molecule tracking (SMT) allows the study of transcription factor (TF) dynamics in the
nucleus, giving important information regarding the diffusion and binding behavior of these …

Background Functional compartmentalization has emerged as an important factor
modulating the kinetics and specificity of biochemical reactions in the nucleus, including …

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor (TF) that controls
the tissue-and gene-specific transactivation and transrepression of thousands of target …

Pluripotency maintenance requires transcription factors (TFs) that induce genes necessary
to preserve the undifferentiated state and repress others involved in differentiation. Recent …

Steroid receptors (SRs) encompass a family of transcription factors that regulate the
expression of thousands of genes upon binding to steroid hormones and include the …