After more than a century of active research, the notion that the human fetal environment is
sterile and that the neonate's microbiome is acquired during and after birth was an accepted …

The infant microbiome plays an essential role in human health and its assembly is
determined by maternal–offspring exchanges of microbiota. This process is affected by …

Humans and their microbiomes have coevolved as a physiologic community composed of
distinct body site niches with metabolic and antigenic diversity. The placental microbiome …

Highlights•F. nucleatum is an oral commensal implicated in oral infections, adverse
pregnancy outcomes, GI disorders, and various other human diseases.•F. nucleatum can …

Fusobacterium nucleatum (Fn) has been associated with colorectal cancer (CRC), but
causality and underlying mechanisms remain to be established. We demonstrate that Fn …

In January 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human
Development invited an expert panel to a workshop to address numerous knowledge gaps …

Periodontal diseases are considered not only to affect tooth‐supporting tissues but also to
have a cause‐and‐effect relationship with various systemic diseases and conditions, such …

The colonization of the gut with microbes in early life is critical to the developing newborn
immune system, metabolic function and potentially future health. Maternal microbes are …

Periodontal disease is very common during pregnancy. Although it has been linked to
adverse pregnancy outcomes, systematic reviews have reached discrepant conclusions on …

Adverse pregnancy outcomes (APO s) have been defined as (a) pre‐term birth, when there
is a delivery before 37 completed weeks (< 259 days);(b) pre‐eclampsia, which is a …