The clinical effect of sperm DNA damage in assisted reproduction has been a controversial
topic during recent decades, leading to a variety of clinical practice recommendations. While …

OBJECTIVE: To review the mechanisms responsible for DNA fragmentation in human
sperm, including those occurring during spermatogenesis and transport through the …

Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

DNA damage in the male germ line has been linked with a variety of adverse clinical
outcomes including impaired fertility, an increased incidence of miscarriage and an …

Reactive oxygen metabolites are known to disrupt sperm-oocyte fusion, sperm movement,
and DNA integrity; however, the relative sensitivities of these elements to oxidative stress …

Objective: To examine the relationship between sperm chromatin defects, evaluated by the
flow cytometric (FCM) sperm chromatin structure assay (SCSA), and the probability of a …

The literature contains conflicting evidence regarding the existence of DNA damage in
spermatozoa from infertile male patients. To examine this phenomenon, we have studied …

Defective sperm function is the largest single defined cause of human infertility and one of
the major reasons we are witnessing an exponential increase in the uptake of assisted …

The objective of this study was to determine the incidence of DNA fragmentation in human
sperm, and to correlate any detected DNA damage with semen analysis parameters and …

DNA damage in human spermatozoa has been associated with a range of adverse clinical
outcomes, including infertility, abortion, and disease in the offspring. We have advanced a …