miR-21 is one of the most highly expressed members of the small non-coding microRNA
family in many mammalian cell types. Its expression is further enhanced in many diseased …

Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation
and to allow for tissue repair and the return to homeostasis after infection and tissue injury …

The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the
transcription factor NF-κB and suppresses interleukin 10 (IL-10). Here we found that mice …

MicroRNAs (miRNAs) are small noncoding, double-stranded RNA molecules that can
mediate the expression of target genes with complementary sequences. About 5,300 human …

Abstract Changes in the patterns of gene expression are widely believed to underlie many of
the phenotypic differences within and between species. Although much emphasis has been …

Chronic inflammation and infection are major causes of cancer. There are continued
improvements to our understanding of the molecular connections between inflammation and …

MicroRNAs have essential functional roles in brain development and neuronal specification
but their roles in neurodegenerative diseases such as Alzheimer's disease (AD) is unknown …

Susceptibility to Crohn's disease, a complex inflammatory disease, is influenced by common
variants at many loci. The common exonic synonymous SNP (c. 313C> T) in IRGM, found in …

Worldwide, the total incidence of cutaneous melanoma is higher in men than in women, with
some differences related to ethnicity and age and, above all, sex and gender. Differences …

The discovery of micro RNA s (miRNAs) in the early 1990's has revolutionized our thinking
of post‐transcriptional gene control. miRNAs are involved in the regulation of almost every …