Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

Primary sclerosing cholangitis is the classic hepatobiliary manifestation of inflammatory
bowel disease and is generally chronic and progressive. Patients frequently present with …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

T helper (Th) 17 cells are important for host defense against bacteria and fungi, but are also
involved in the pathogenesis of autoimmune diseases. In primary sclerosing cholangitis …

Cholangiopathies encompass various biliary diseases affecting the biliary epithelium,
resulting in cholestasis, inflammation, fibrosis, and ultimately liver cirrhosis. Primary biliary …

Background & Aims Recently, genome wide association studies in primary sclerosing
cholangitis (PSC) revealed associations with gene polymorphisms that potentially could …

Clinical vignette A 21-year old woman was admitted to hospital with a two-week history of
painless jaundice, fatigue and anorexia having previously been fit and well. One month prior …

Vancomycin has been shown to affect tumor necrosis factor-alpha (TNF-α) pathways as an
immunomodulator; this is thought to be separate from its function as an antibiotic [1] …

Understanding the hepatic regenerative process has clinical interest as the effectiveness of
many treatments for chronic liver diseases is conditioned by efficient liver regeneration …