The adolescent brain and age-related behavioral manifestations

LP Spear - Neuroscience & biobehavioral reviews, 2000 - Elsevier
To successfully negotiate the developmental transition between youth and adulthood,
adolescents must maneuver this often stressful period while acquiring skills necessary for …

The neurobiology of social play behavior in rats

LJMJ Vanderschuren, RJM Niesink… - … & Biobehavioral Reviews, 1997 - Elsevier
Social play behavior is one of the earliest forms of non-mother-directed social behavior
appearing in ontogeny in mammalian species. During the last century, there has been a lot …

Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis

EC Azmitia - Brain research bulletin, 2001 - Elsevier
Evolutionarily, serotonin existed in plants even before the appearance of animals. Indeed,
serotonin may be tied to the evolution of life itself, particularly through the role of tryptophan …

Serotonergic vulnerability and depression: assumptions, experimental evidence and implications

LAW Jans, WJ Riedel, CR Markus, A Blokland - Molecular psychiatry, 2007 - nature.com
In recent years, the term serotonergic vulnerability (SV) has been used in scientific literature,
but so far it has not been explicitly defined. This review article attempts to elucidate the SV …

Prenatal substance exposure: effects on attention and impulsivity of 6-year-olds

SL Leech, GA Richardson, L Goldschmidt… - Neurotoxicology and …, 1999 - Elsevier
Attention and impulsivity of prenatally substance-exposed 6 year olds were assessed as part
of a longitudinal study. Most of the women were light to moderate users of alcohol and …

New evidence for neurotransmitter influences on brain development

P Levitt, JA Harvey, E Friedman, K Simansky… - Trends in …, 1997 - cell.com
The early appearance of monoamine systems in the developing mammalian CNS suggests
that they play a role in neural development. We review data from two model systems that …

Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism?

PM Whitaker-Azmitia - International Journal of Developmental …, 2005 - Elsevier
The hypothesis explored in this review is that the high levels of serotonin in the blood seen
in some autistic children (the so-called hyperserotonemia of autism) may lead to some of the …

Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood

GH Moll, C Mehnert, M Wicker, N Bock… - Developmental Brain …, 2000 - Elsevier
The binding parameters of highly selective ligands of serotonin (5-HT) transporters ([3H]
paroxetine), noradrenaline (NE) transporters ([3H] nisoxetine), and of dopamine (DA) …

Behavioral consequences of abnormal cortical development: insights into developmental disabilities

J Berger-Sweeney, CF Hohmann - Behavioural brain research, 1997 - Elsevier
Cerebral cortical development occurs in precisely-timed stages that can be divided into
neurogenesis, neuronal migration and neuronal differentiation. These events occur during …

Serotonin transporter messenger RNA in the developing rat brain: early expression in serotonergic neurons and transient expression in non-serotonergic neurons

SR Hansson, E Mezey, BJ Hoffman - Neuroscience, 1998 - Elsevier
Serotonin has been shown to affect the development of the mammalian nervous system. The
serotonin transporter is a major factor in regulating extracellular serotonin levels. Using in …