[HTML][HTML] Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

D Nolfi-Donegan, A Braganza, S Shiva - Redox biology, 2020 - Elsevier
The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

Functions of ROS in macrophages and antimicrobial immunity

M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Mitochondrial electron transport chain, ROS generation and uncoupling

RZ Zhao, S Jiang, L Zhang… - … journal of molecular …, 2019 - spandidos-publications.com
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

[HTML][HTML] Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis

Y Hirata, R Cai, A Volchuk, BE Steinberg, Y Saito… - Current Biology, 2023 - cell.com
The ongoing metabolic and microbicidal pathways that support and protect cellular life
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …

[HTML][HTML] Mitochondrial iron–sulfur clusters: Structure, function, and an emerging role in vascular biology

AD Read, RET Bentley, SL Archer, KJ Dunham-Snary - Redox biology, 2021 - Elsevier
Abstract Iron-sulfur (Fe–S) clusters are essential cofactors most commonly known for their
role mediating electron transfer within the mitochondrial respiratory chain. The Fe–S cluster …

The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies

JS Bhatti, GK Bhatti, PH Reddy - … et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders

M Ayaz, A Sadiq, M Junaid, F Ullah, M Ovais… - Frontiers in aging …, 2019 - frontiersin.org
Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich
foods significantly improve cognitive capabilities, inhibit or delay the senescence process …