BACKGROUND: Worldwide, the Brugada syndrome has been recognized as an important
cause of sudden cardiac death in individuals at a relatively young age. Importantly, many …

Abstract Levetiracetam (Keppra®, E Keppra®) is an established second-generation anti-
epileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive …

Discovering the unintended 'off-targets' that predict adverse drug reactions is daunting by
empirical methods alone. Drugs can act on several protein targets, some of which can be …

Sodium channels play an important role in the neuronal network by transmitting electrical
impulses rapidly throughout cells and cell networks, thereby coordinating higher processes …

In an effort to enhance access to information available in the National Cancer Institute's
(NCI) anticancer drug-screening database, a new suite of Internet accessible …

INTRODUCTION: Cardiac liabilities represent a major cause of recent withdrawal of
marketed drugs and also for the high attrition rate evidenced during late stage drug …

Diphenhydramine, a common ingredient in over-the-counter medications, is often taken in
overdose. Toxicity is usually limited to anticholinergic symptoms. However, because …

Cannabidiol (CBD), one of the cannabinoids from the cannabis plant, can relieve the
myotonia resulting from sodium channelopathy, which manifests as repetitive discharges of …

More than 400 genes are known that encode ion channel subunits. In addition, alternative
splicing and heteromeric assembly of different subunits increase tremendously the variety of …

The development of novel anticonvulsant drugs with improved efficacy for the treatment of
epilepsy is hindered by a lack of information regarding the quantitative relationship between …