Regulation of lung development and regeneration by the vascular system
N Woik, J Kroll - Cellular and molecular life sciences, 2015 - Springer
Blood vessels have been described a long time ago as passive circuits providing sufficient
blood supply to ensure proper distribution of oxygen and nutrition. Blood vessels are mainly …
blood supply to ensure proper distribution of oxygen and nutrition. Blood vessels are mainly …
[HTML][HTML] The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease
P Oak, A Hilgendorff - Molecular and Cellular Pediatrics, 2017 - Springer
The development of neonatal chronic lung disease (nCLD), ie, bronchopulmonary dysplasia
(BPD) in preterm infants, significantly determines long-term outcome in this patient …
(BPD) in preterm infants, significantly determines long-term outcome in this patient …
Expression of HIF-1α, VEGF and EPO in peripheral blood from patients with two cardiac abnormalities associated with hypoxia
ML Lemus-Varela, ME Flores-Soto… - Clinical …, 2010 - Elsevier
OBJECTIVES: HIF-1α (hypoxia-inducible factor-1 alpha) mediates the responses of
mammalian cells to hypoxia/ischemia by inducing the expression of adaptive gene products …
mammalian cells to hypoxia/ischemia by inducing the expression of adaptive gene products …
Hypoxia-inducible factors promote alveolar development and regeneration
A Vadivel, RS Alphonse, N Etches… - American journal of …, 2014 - atsjournals.org
Understanding how alveoli and the underlying capillary network develop and how these
mechanisms are disrupted in disease states is critical for developing effective therapies for …
mechanisms are disrupted in disease states is critical for developing effective therapies for …
SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype
L Raghoebir, ERM Bakker, JC Mills… - Journal of molecular …, 2012 - academic.oup.com
Various factors play an essential role in patterning the digestive tract. During development,
Sox2 and Cdx2 are exclusively expressed in the anterior and the posterior parts of the …
Sox2 and Cdx2 are exclusively expressed in the anterior and the posterior parts of the …
Antenatal hypoxia and pulmonary vascular function and remodeling
DG Papamatheakis, AB Blood, JH Kim… - Current vascular …, 2013 - ingentaconnect.com
This review provides evidence that antenatal hypoxia, which represents a significant and
worldwide problem, causes prenatal programming of the lung. A general overview of lung …
worldwide problem, causes prenatal programming of the lung. A general overview of lung …
Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia
DS Mous, HM Kool… - … of Physiology-Lung …, 2016 - journals.physiology.org
Patients with congenital diaphragmatic hernia (CDH) suffer from severe pulmonary
hypertension attributable to altered development of the pulmonary vasculature, which is …
hypertension attributable to altered development of the pulmonary vasculature, which is …
[HTML][HTML] Postnatal growth restriction augments oxygen-induced pulmonary hypertension in a neonatal rat model of bronchopulmonary dysplasia
S Wedgwood, C Warford, SC Agvateesiri, P Thai… - Pediatric …, 2016 - nature.com
Background: Prematurity and fetal growth restriction are risk factors for pulmonary
hypertension (PH) in infants with bronchopulmonary dysplasia (BPD). Neonatal rats develop …
hypertension (PH) in infants with bronchopulmonary dysplasia (BPD). Neonatal rats develop …
[HTML][HTML] Changes in vasoactive pathways in congenital diaphragmatic hernia associated pulmonary hypertension explain unresponsiveness to pharmacotherapy
DS Mous, MJ Buscop-van Kempen, RMH Wijnen… - Respiratory …, 2017 - Springer
Background Patients with congenital diaphragmatic hernia (CDH) have structural and
functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to …
functional different pulmonary vessels, leading to pulmonary hypertension. They often fail to …
Premature differentiation of vascular smooth muscle cells in human congenital diaphragmatic hernia
I Sluiter, I van der Horst, P van der Voorn… - Experimental and …, 2013 - Elsevier
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly
characterized by the herniation of abdominal organs into the chest cavity. The high mortality …
characterized by the herniation of abdominal organs into the chest cavity. The high mortality …