DNA double-strand breaks (DSBs) are common lesions that continually threaten genomic
integrity. Failure to repair a DSB has deleterious consequences, including cell death …

The discovery of the severe combined immunodeficiency (scid) mouse mutation has
provided a tool for establishment of small animal models as hosts for the in vivo analysis of …

We have generated mice that carry a germline mutation in which a large portion of the RAG-
2 coding region is deleted. Homozygous mutants are viable but fail to produce mature B or T …

XRCC4 was identified via a complementation cloning method that employed an ionizing
radiation (IR)-sensitive hamster cell line. By gene-targeted mutation, we show that XRCC4 …

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production.
The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in …

Murine cells homozygous for the severe combined immune deficiency mutation (scid) and
V3 mutant hamster cells fall into the same complementation group and show similar defects …

The DNA-end-joining reactions used for repair of double-strand breaks in DNA and for V (D)
J recombination, the process by which immunoglobulin and T-cell antigen-receptor genes …

XRCC4 is a non-homologous end-joining protein employed in DNA double strand break
repair and in V (D) J recombination,. In mice, XRCC4-deficiency causes a pleiotropic …

Classical nonhomologous end joining (C-NHEJ) is one of the two major known pathways for
the repair of DNA double-strand breaks (DSBs) in mammalian cells. Our understanding of C …

MICE homozygous for the scid mutation on chromosome 16 have a severe combined
immune deficiency1, 2 as a result of their inability to correctly rearrange their …