Dyspnea is the most common symptom experienced by patients with chronic obstructive
pulmonary disease (COPD). To avoid exertional dyspnea, many patients adopt a sedentary …

Dyspnea is a distressing, debilitating, and near-ubiquitous symptom affecting patients with
COPD. In addition to the functional consequences of dyspnea, which include activity …

Health-related quality of life (HRQoL), though rarely considered as a primary endpoint in
clinical trials, may be the single outcome reflective of patient priorities when living with a …

Breathing is peculiar among autonomic functions through several characteristics. It
generates a very rich afferent traffic from an array of structures belonging to the respiratory …

Advanced respiratory disease imposes a greater symptom burden than many cancers but
not does have comparable recognition of the need for supportive and palliative care or the …

A person's expectations and mood are major contributors to the function of the brain
networks that generate perceptions of breathlessness. Breathlessness, therefore, arises …

Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease whereby its
main pathological drivers of disability and damage are vascular injury, inflammatory cell …

In the last American Thoracic Society (ATS) statement, dyspnea was defined as “a subjective
experience of breathing discomfort that consists of qualitatively distinct sensations that vary …

Chronic breathlessness is a disabling and distressing condition for which there is a growing
evidence base for a range of interventions. Non-pharmacological interventions are the …

Activity-related breathlessness is the most problematic symptom of chronic obstructive
pulmonary disease (COPD), arising from complex interactions between peripheral …