Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Tumor-associated angiogenesis is a key target for anti-cancer therapy. The imbalance
between pro-angiogenic and anti-angiogenic signals elicited by tumor cells or tumor …

Abstract Prolyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling
pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases …

Alkaloids are among the natural phytochemicals contained in functional foods and
nutraceuticals and have been suggested for the prevention and/or management of oxidative …

Cancer is still considered a “hopeless case”, which seriously endangers human health.
Therefore, it is of great significance to research and develop novel anticancer drugs. Active …

Abstract Glutamyl-prolyl-tRNA synthetase 1 (EPRS1) is known to associated with fibrosis
through its catalytic activity to produce prolyl-tRNA. Although its catalytic inhibitor …

While numerous targeted therapies have been recently adopted to improve the treatment of
hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to …

Reserpine is a natural indole alkaloid isolated from Rauwolfia serpentina and has potent
antioxidant, antimicrobial, and anti-mutagenic properties. Accordingly, this study aimed to …

Traditional Chinese medicine (TCM) are both historically important therapeutic agents and
important source of new drugs. Halofuginone (HF), a small molecule alkaloid derived from …

The biomedical field faces an ongoing challenge in developing more effective anti-cancer
medication due to the significant burden that cancer poses on human health. Extensive …