Abstract The Canadian Consensus Working Group has updated its evaluation of the
literature pertaining to statin intolerance and adverse effects. This overview introduces a …

Introduction: Statins reduce the risk of cardiovascular morbidity and mortality in patients with
or at risk for cardiovascular disease and their use is expanding, especially in elderly. Statins …

Abstract Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are currently
the most effective lipid-lowering drugs, effectively reducing the plasma total cholesterol and …

Novel antiplatelet drugs, including ticagrelor, are being successively introduced into the
therapy of atherothrombotic conditions due to their superiority over a standard combination …

Introduction: Chronic subdural hematoma (CSDH) is a common neurosurgical disease,
whose incidence has been steadily increasing with our aging population. While not …

Introduction Persons aged more than 65 years may be more prone to suffer from chronic
diseases and comorbidities (as demonstrated by the recent COVID-19 pandemics) and are …

Exosomes are endogenous nanoparticles with a lipid bilayer membrane whose natural
function as carriers of biological materials has attracted much attention. The ability of …

The introduction of ticagrelor, one of the first directly-acting oral antiplatelet drugs, provided
new possibilities in the prevention of thrombotic events in patients with acute coronary …

Introduction: Ticagrelor is a first drug of a new chemical class cyclopentyltriazolopyrimidines.
It is an antiplatelet agent with a unique mechanism of action, allowing a direct and reversible …

Ever since evidence about the increased risk of stent thrombosis with drug eluting stents
(DES) surfaced in 2005, the Food and Drug Administration (FDA) has recommended the use …