Significance: Iron and oxygen are intimately linked: iron is an essential nutrient utilized as a
cofactor in enzymes for oxygen transport, oxidative phosphorylation, and metabolite …

Canonical functions of mitochondria include the regulation of cellular survival, orchestration
of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling …

Persistent safety concerns have stalled the development of viable hemoglobin (Hb)-based
oxygen carriers (HBOCs). HBOCs have several advantages over human blood, including …

Vascular diseases are multifactorial, often requiring multiple challenges, or 'hits', for their
initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event …

Sepsis is a complex clinical syndrome characterized by a systemic inflammatory response to
an infective insult. This process often leads to widespread tissue injury and multiple organ …

Diabetic nephropathy (DN) is a well-described complication of diabetes mellitus and the
leading cause of end stage renal disease (ESRD). Although increased albuminuria has …

Nuclear factor‐(erythroid‐derived 2) like 2 (NFE2L2, NRF2) is a key transcriptional activator
of the antioxidant response pathway and is closely related to erythroid transcription factor …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), is an exclusively
human Gram-positive bacterial pathogen ranked among the 'top 10'causes of infection …

Abstract Alpha-1-microglobulin (A1M) is a small protein found intra-and extracellularly in all
tissues of vertebrates. The protein was discovered 40 years ago and its physiological role …

Hemolysis and consequent release of cell-free hemoglobin (CFHb) impair vascular nitric
oxide (NO) bioavailability and cause oxidative and inflammatory processes. Hydroxyurea …