The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for
protein quality control and homeostasis. Dysregulation of the UPS has been implicated in …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt,
Notch and epidermal growth factor signals. Here we find that the related RNF43 and ZNRF3 …

Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key
regulated step of the Wnt pathway. It is incompletely understood how the Axin1 complex …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Aberrant activation of Wnt/β-catenin signaling plays a central role in the pathogenesis of a
wide variety of malignancies and is typically caused by mutations in core Wnt pathway …

Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue
homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a …

The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …