The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Mitochondria carry their own genetic information encoding for a subset of protein-coding
genes and translational machinery essential for cellular respiration and metabolism. Despite …

Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in
systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from …

Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …

Mitochondria host key metabolic processes vital for cellular energy provision and are central
to cell fate decisions. They are subjected to unique genetic control by both nuclear DNA and …

Over the last decade, Haplogrep has become a standard tool for haplogroup classification in
the field of human mitochondrial DNA and is widely used by medical, forensic, and …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Genomic databases of allele frequency are extremely helpful for evaluating clinical variants
of unknown significance; however, until now, databases such as the Genome Aggregation …

The development of curative treatments for mitochondrial diseases, which are often caused
by mutations in mitochondrial DNA (mtDNA) that impair energy metabolism and other …