Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

PD Cani, C Depommier, M Derrien, A Everard… - Nature Reviews …, 2022 - nature.com
Ever since Akkermansia muciniphila was discovered and characterized two decades ago,
numerous studies have shown that the lack or decreased abundance of this commensal …

Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties

A Pellegrino, G Coppola, F Santopaolo, A Gasbarrini… - Nutrients, 2023 - mdpi.com
The gut microbiota plays a critical role in the modulation of host metabolism and immune
response, and its impairment has been implicated in many gastrointestinal and …

Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly

N Karcher, E Nigro, M Punčochář, A Blanco-Míguez… - Genome biology, 2021 - Springer
Background Akkermansia muciniphila is a human gut microbe with a key role in the
physiology of the intestinal mucus layer and reported associations with decreased body …

The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury

S Keshavarz Azizi Raftar, F Ashrafian… - Microbiology …, 2021 - Am Soc Microbiol
Akkermansia muciniphila, as a member of the gut microbiota, has been proposed as a next-
generation probiotic. Liver fibrosis is the main determinant of liver dysfunction and mortality …

Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

J Yan, Y Pan, W Shao, C Wang, R Wang, Y He… - Microbiome, 2022 - Springer
Background Vascular calcification is a major cause of the high morbidity and mortality of
cardiovascular diseases and is closely associated with the intestinal microbiota. Short-chain …

Akkermansia muciniphila, a New Generation of Beneficial Microbiota in Modulating Obesity: A Systematic Review

JN Abuqwider, G Mauriello, M Altamimi - Microorganisms, 2021 - mdpi.com
Obesity is a complex syndrome and is recognized as the ultimate pathway of many chronic
diseases. Studies using Akkermansia muciniphila supplementation strategy have proved to …

Function of Akkermansia muciniphila in type 2 diabetes and related diseases

J Li, G Yang, Q Zhang, Z Liu, X Jiang… - Frontiers in Microbiology, 2023 - frontiersin.org
The prevalence of type 2 diabetes (T2D) is increasing worldwide, with many patients
developing long-term complications that affect their cardiovascular, urinary, alimentary, and …

Research progress of gut microbiota and obesity caused by high-fat diet

S Fan, S Chen, L Lin - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
Obesity, a chronic metabolic disorder caused by an energy imbalance, has been
increasingly prevalent and poses a global health concern. The multifactorial etiology of …

Dietary pulses as a means to improve the gut microbiome, inflammation, and appetite control in obesity

HS John, É Doucet, KA Power - Obesity Reviews, 2023 - Wiley Online Library
A dysbiotic intestinal microbiome has been linked to chronic diseases such as obesity,
which may suggest that interventions that target the microbiome may be useful in treating …

Comparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice

F Ashrafian, S Keshavarz Azizi Raftar, A Shahryari… - Scientific reports, 2021 - nature.com
Recently, Akkermansia muciniphila an anaerobic member of the gut microbiota, has been
proposed as a next-generation probiotic. The aim of this study was evaluation of the effect of …