S-adenosylmethionine in Liver Health, Injury, and Cancer
SC Lu, JM Mato - Physiological reviews, 2012 - journals.physiology.org
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …
methyl donor synthesized in all mammalian cells but most abundantly in the liver …
Many paths to methyltransfer: a chronicle of convergence
HL Schubert, RM Blumenthal, X Cheng - Trends in biochemical sciences, 2003 - cell.com
Abstract S-adenosyl-l-methionine (AdoMet) dependent methyltransferases (MTases) are
involved in biosynthesis, signal transduction, protein repair, chromatin regulation and gene …
involved in biosynthesis, signal transduction, protein repair, chromatin regulation and gene …
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme
T Lotta, J Vidgren, C Tilgmann, I Ulmanen, K Melen… - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received January 11, 1995® abstract: Human soluble (S) and
membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1. 1.6) enzymes have …
membrane-bound (MB) catechol O-methyltransferase (COMT, EC 2.1. 1.6) enzymes have …
Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation
MR Bauerle, EL Schwalm, SJ Booker - Journal of Biological Chemistry, 2015 - ASBMB
Radical S-adenosylmethionine (SAM) enzymes use the oxidizing power of a 5′-
deoxyadenosyl 5′-radical to initiate an amazing array of transformations, usually through …
deoxyadenosyl 5′-radical to initiate an amazing array of transformations, usually through …
Crystal structure of catechol O-methyltransferase
J Vidgren, LA Svensson, A Liljas - Nature, 1994 - nature.com
Abstract CATECHOL O-methyltransferase (COMT, EC 2.1. 1.6) is important in the central
nervous system because it metabolizes catecholamine neurotransmitters such as dopamine …
nervous system because it metabolizes catecholamine neurotransmitters such as dopamine …
[HTML][HTML] The structural biology of oestrogen metabolism
MP Thomas, BVL Potter - The Journal of steroid biochemistry and …, 2013 - Elsevier
Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product.
The reactions catalysed include aromatisation, oxidation, reduction, sulfonation …
The reactions catalysed include aromatisation, oxidation, reduction, sulfonation …
Radical-mediated enzymatic methylation: a tale of two SAMS
Methylation is an essential and ubiquitous reaction that plays an important role in a wide
range of biological processes. Most biological methylations use S-adenosylmethionine …
range of biological processes. Most biological methylations use S-adenosylmethionine …
A Radically Different Mechanism for S-Adenosylmethionine–Dependent Methyltransferases
TL Grove, JS Benner, MI Radle, JH Ahlum, BJ Landgraf… - Science, 2011 - science.org
Methylation of small molecules and macromolecules is crucial in metabolism, cell signaling,
and epigenetic programming and is most often achieved by S-adenosylmethionine (SAM) …
and epigenetic programming and is most often achieved by S-adenosylmethionine (SAM) …
Catechol‐O‐methyltransferase and Its Inhibitors in Parkinson's Disease
Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of
dopaminergic neurons, with consequent reduction in striatal dopamine levels leading to …
dopaminergic neurons, with consequent reduction in striatal dopamine levels leading to …
Catechol-O-Methyltransferase (COMT)-mediated methylation metabolism of endogenous bioactive catechols and modulation by endobiotics and xenobiotics …
B Zhu - Current drug metabolism, 2002 - ingentaconnect.com
The metabolic O-methylation of endogenous catecholamines and other catechols catalyzed
by catechol-O-methyltransferase (COMT EC 2.1. 1.6) was first described by Dr. Julix Axelrod …
by catechol-O-methyltransferase (COMT EC 2.1. 1.6) was first described by Dr. Julix Axelrod …